BRS Pathology (Board Review Series)
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- Over 450 USMLE-style questions, answers, and rationales both electronically and in print to reinforce your pathology review
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- Correlation boxes emphasize connections between pathology and clinical medicine
- A FREE companion website with access to the E-book, image bank, and an interactive question bank featuring all the questions from the book for engaging, effective test preparation!
(IL-1) and tumor necrosis factor (TNF). 17 18 BRS Pathology b. L-selectins are expressed on neutrophils and bind to endothelial mucin-like molecules such as GlyCam-1. c. E- and P-selectins are expressed on endothelial cells and bind to oligosaccharides such as sialyl-Lewis X on the surface of leukocytes. P-selectins, stored in endothelial Weibel-Palade bodies and platelet alpha granules, relocate to the plasma membrane after stimulation by mediators such as histamine and thrombin. 3.
Aspirin has been shown to prevent recurrent myocardial infarction through its ability to inhibit the synthesis of (A) (B) (C) (D) (E) adenosine diphosphate (ADP). leukotriene B4 (LTB4). nitric oxide (NO). prostaglandin I2 (PGI2). thromboxane A2 (TxA2). 10. A bedridden elderly patient experiences the sudden onset of pleuritic pain and hemoptysis. The underlying lesion that led to this complication was most likely located in which of the following sites? 6. An 86-year-old man with a
three major variants: (a) Type I, or adult Gaucher disease, which accounts for about 80% of cases, is characterized by hepatosplenomegaly, erosion of the femoral head and of the long bones, and mild anemia. Gaucher cells are seen in the liver, spleen, lymph nodes, and bone marrow. A normal lifespan is possible. (b) Type II, or infantile Gaucher disease, is marked by severe CNS involvement and results in death before 1 year of age. There is no detectable glucocerebrosidase in the tissues.
or degradation of glycogen. a. von Gierke disease is glycogen storage disease type I, or hepatorenal glycogenosis. (1) The cause is a deficiency of glucose-6-phosphatase, with consequent accumulation of glycogen, primarily in the liver and kidney. (2) Characteristics include hepatomegaly and sometimes intractable hypoglycemia. b. Pompe disease is glycogen storage disease type II but can also be classified as a lysosomal storage disease. (1) The cause is a deficiency of α-1,4-glucosidase (a
complication of AIDS? (A) (B) (C) (D) (E) Caseous Coagulative Enzymatic Fibrinoid Liquefactive 13 Chapter 1 Cellular Reaction to Injury 6. A 45-year-old woman is investigated for hypertension and is found to have enlargement of the left kidney. The right kidney is smaller than normal. Contrast studies reveal stenosis of the right renal artery. The size change in the right kidney is an example of which of the following adaptive changes? 8. A 64-year-old woman presents with